10522
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10522
Fluka
Anisomycin from Streptomyces griseolus
BioChemika, ≥96.0% (TLC)
| Synonym: | (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate, Flagecidin |
| CAS Number: | 22862-76-6 |
| Linear Formula: | C14H19NO4 |
| Molecular Weight: | 265.30 |
| Beilstein Registry Number: | 20705 |
| EC Number: | 245-269-7 |
| MDL number: | MFCD00077650 |
Description
| Other Notes | Inhibits formation of the 80S ribosomal complex from 60S subunits.1 |
| Biochem/physiol Actions | Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent. |
Properties
| product line | BioChemika |
| assay | ≥96.0% (TLC) |
| solubility | methanol: 20 mg/mL, clear, colorless to faintly yellow |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | BZ9800000 |
Related Products
| Replaced by | A9789, Anisomycin from Streptomyces griseolus |
References
| Cited Reference | 1. W.J.van Venrooij et al. Biochemistry 16, 2343, (1977) Abstract |
| Merck | Merck 13,673 |
| Beilstein | Beil. 21,V,5,523 |
